|System(s)||Game Boy Advance|
The concluding story in the Metroid series, Metroid Fusion follows Samus Aran to the Biologic Space Laboratories to investigate an explosion. There, she learns that the station is swarming with X Parasites, virions that can infect and enslave other creatures. She must wipe them out to protect the Galactic Federation from the underestimated destructive power of the X Parasites.
- Collect all suit upgrades, energy tanks, and weapon expansions. These include:
- 48 missile tanks, for a total of 250 missiles.
- 32 power bomb tanks, for a total of 74 power bombs.
- 20 energy tanks.
- (Optional) The image that appears when revealing your final game time and item percentage varies depending on your completion time and percentage, with the hardest appearing for clearing the game in under 2 hours with 100% of items collected.
- (Optional) The Japanese version of the game includes 3 difficulty modes (Easy, Normal, and Hard), with Normal being equivalent to the only difficulty in Western releases. The game also has 6 exclusive ending pictures, for the game's "Child Mode" and for beating the game with 100% of items in under 2 hours on Hard. Beating the game unlocks a gallery, showing all ending pictures the player has achieved. 
- ↑ The Cutting Room Floor - Metroid Fusion: Regional Differences, https://tcrf.net/Metroid_Fusion#Regional_Differences
Master Run IdeasEdit
- Speed Run
- Minimalist Run
- Major upgrades cannot be skipped, and are not counted in the collection percentage. All expansions can be skipped, aside from one Missile Tank in Sector 3. As such, 1% is the intended lowest percentage you can obtain.
- Collecting 0% of items is possible, however it requires a glitch, or a very difficult Shinespark to accomplish.
The map will show unattained expansions as a circle in the room, and obtained expansions as dots. In addition, after beating the game, a Metroid icon is displayed next to your file on the File Select screen. On this file, any locked doors in the endgame section will be unlocked, allowing you to fully traverse the BSL. The pause screen will also display the number of each expansion you have collected, and will show an icon if you have collected every expansion of a given type in your current sector. As such, it is recommended that you clean up the items in the game in this state, although these effects will persist if you select "Start Over" instead of "Continue" when selecting a file.
There is however still some ambiguity in this (such as when there are two items in the same map grid), so a thorough player may wish to use a checklist to avoid a long search for the remaining expansions at the end of the game.